| Pair Name | Platycodin D, Oxaliplatin | ||
| Phytochemical Name | Platycodin D (PubChem CID: 162859 ) | ||
| Anticancer drug Name | Oxaliplatin (PubChem CID: 9887053 ) | ||
| Structure of Phytochemical |
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2D
MOL
3D
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| Structure of Anticancer Drug |
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| Pair Name | Platycodin D, Oxaliplatin | |||
| Disease Info | [ICD-11: 2B91.Z] | Colorectal cancer | Investigative | |
| Biological Phenomena | Inhibition-->Cell metastasis | |||
| Gene Regulation | Down-regulation | Phosphorylation | YAP1 | hsa10413 |
| Down-regulation | Phosphorylation | WWTR1 | hsa25937 | |
| Up-regulation | Expression | CDKN1A | hsa1026 | |
| Up-regulation | Expression | PSMD9 | hsa5715 | |
| Down-regulation | Phosphorylation | AKT1 | hsa207 | |
| Up-regulation | Expression | MKI67 | hsa4288 | |
| In Vitro Model | LoVo | Colon adenocarcinoma | Homo sapiens (Human) | CVCL_0399 |
| Result | Our results showed that PD is suitable as a promising agent for overcoming oxaliplatin-resistant colorectal cancer. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Platycodin D confers oxaliplatin Resistance in Colorectal Cancer by activating the LATS2/YAP1 axis of the hippo signaling pathway. J Cancer. 2023 Jan 22;14(3):393-402. doi: 10.7150/jca.77322. | Click |
